Lexapro is manufactured by Forest Pharmaceuticals, Inc. Neurotransmitters carry signals from one nerve cell to another.Research suggests that abnormalities in neurotransmitter activity can affect mood and behavior.Sexual dysfunction The SSRIs as a class produce a variety of sexual side effects, including anorgasmia, decreased libido, impotence, and delayed ejaculation.
Thus, the medications work by allowing the body to make the best use of the reduced amounts of serotonin that it has at the time.The SSRIs represent the first rationally designed class of psychotropic medications.The strategy behind rational drug development is to design a new drug that is capable of affecting a specific neural site of action (e.g., uptake pumps, receptors) while avoiding effects on other site of actions.Also, SSRIs have very different molecular structures. Zoloft (Sertraline hydrochloride) was the second SSRI to come to market in the United States, and it was approved by the FDA in December 30, 1991. Paxil (Paroxetine hydrochloride) was the third SSRI to come to market in the United States and was approved by the FDA in December 29, 1992. Chemical structure of Paroxetine differs from other SSRIs by having a piperidine ring.The first drug in the SSRI class was Prozac (Fluoxetine), which hit the United States market in 1987. Luvox (Fluvoxamine maleate) was the next SSRI FDA approved in December 05, 1994.